No, there is no way to predict when a slot machine is going to hit a jackpot or to determine which machine is going to be lucky. Slot machines are programmed to use a random number generator (RNG) to determine the outcome of each spin, and the RNG generates random and unpredictable results.

$39.7 Million  Excalibur Casino, Las Vegas\n\n The largest jackpot on a slot machine at any casino took place at the Excalibur Casino in Las Vegas. Way back in 2003, the winner was a young software engineer who chose to remain anonymous. This gambler from Los Angeles dropped a mere $100 into the slot machine.